One of the reasons why James Madison was in favor of ratifying the Constitution is because he thought it would help prevent disagreement by being a supreme power over the states--making it more difficult for issues between the states to go unresolved.
The silk road, I do believe. lolol
All the events and trends that have happened in the past until present on local, national and global sphere are interrelated.
Let's take an example of Kosovo: who would have though that the fate of Kosovo is dependent on Independence movement in Spain? but it is is, as Spain doesn't want to recognize Kosovo, as it's afraid that it will have secession too. And Kosovo needs Spain's recognition to be a full member of UN.
A. Bombing more than 60 Japanese cities, C. Declaring a Soviet attack on Japan, and E. Issuing the Potsdam Declaration