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julsineya [31]
1 year ago
11

What amino acid can be obtained by the reductive amination of γ-ketoglutaric acid

Biology
1 answer:
Svetradugi [14.3K]1 year ago
5 0

Answer:

Glutamic acid

Explanation:

Reductive amination is a form of amination that involves the conversion of a carbonyl group to an amine via an intermediate imine. The carbonyl group is most commonly a ketone or an aldehyde. In this reaction, in the presence of enzyme glutamate dehydrogenase, ammonium ion directly combines with alpha-ketoglutaric acid, to form glutamic acid (amino acid) and for this to happen, a reduced coenzyme (NADPH) is required.

The biosynthesis of glutamic acid  can be obtianed from the reductive amination of γ-ketoglutaric acid

γ-Ketoglutaric acid is a common precursor in synthesis of glutamic acid. Addition of NADPH and ammonia or alpha amino acid with   γ-Ketoglutaric acid produces glutamic acid. Enzymes involved in this reduction amination  process are glutamate dehydrogenase and/or transaminase.

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