Answer:
As mentioned in the question, The mitotic spindle is a part of a cell that allows for the movement of sister chromatids to opposite poles of the cell during the later stages of mitosis.
However, if due to any reason, mitotic spindles donot function properly, it will hinder the separation of spindle fibers and chromosomes will not be separated from each other. This is commonly termed a s a condition of Nondisjunction of chrosmosomes where they fail to separate during mitosis. This results in the production of extra chromosomes or missing chromosomes - a condition called aneuploidy.
If this condition occurs in embryos like they have extra or missing chromosomes, they do not survive in main cases and the chances of their survival are only 0.3 percent.
However, if a child is born with such chromosomal defects called aneuploids, they have severe physiological or genetic conditions.
For example: Down syndrome in which there is an extra chromosome 21 in the offspring, this condition is also known as trisomy. In this genetic disease, the offspring manifest a series of physiological problems like mild to moderate intellectual disability,physical growth delays and characteristic facial features.
There are also many other genetic diseases associated with chromosomal non-disjuction such as Turner syndrome, Patau Syndrome Edward’s Syndrome, and Kleinfelter’s Syndrome.
Hope it help!
