Answer:
If predominantly, we can't say of any treatment for progeria, aside from the routine observation of heart and blood vessel (cardiovascular) disease which is important in taking care of the health situation in the affected kids. Treatment relies majorly on the situation and clinical manifestations of the kid. At first, in 1999, the findings of the initial clinical drug trial for kids with an unusual rapid-aging disease, often referred to as Progeria, revealed positive results with a farnesyltransferase inhibitor (FTI), a drug initially designed to treat cancer.
The PATHWAY in gene expression to be TARGETED is progenin formulation---
The Progeria-forming mutation results in the formation of the protein progerin that disrupts the cell activities. Some areas of progerin's toxic impact on the body is due to the formation of a farnesyl group, Â that adheres to the progerin protein aiding it's disruption of the body's cells. FTIs means of action is through inhibition of the adhesion of the farnesyl group to progerin, decreasing the hazardous substances that leads to progerin.
The genetic medicine technique that acts as.an intervention tool gene therapy to regulate the gene that causes the stimulation and formation of the protein progenin.
Escalated cardiovascular disease results in death in the case of Progeria.
It's worthwhile to note that if the basic blood vessels can with time get better as a result of treatment, the treatment shows positive results. Slowing down stroke and aging manifestations will boost the chances of treatment.
A series of steps designed to solve problems and answer questions is "a scientific method".
Answer:
Steroid hormones that enter the cell activate receptors. These hormone-receptor complexes then bind HREs and influence gene expression.
Explanation:
Mechanism of action of steroid hormones is as follows:
- Steroid hormone enters cell and bind to the receptor.
- Translocation of activated receptor- ligand complex into nucleus.
- This complex then bind to another receptor on the chromatin.
- Steroid receptors form dimers.
- Act on DNA
- These hormone-receptor complexes then bind HREs and influence gene expression.
- Augmentation or Suppression of transcription.
