<h3>Question from alternative source</h3>
Many different types of mutations can occur within the body. Cystic fibrosis is a genetic disorder that is caused by different mutations within the CFTR gene. One mutation in the CFTR gene that leads to cystic fibrosis causes translation to end earlier in the gene sequence. Which type of mutation causes this translation error that leads to cystic fibrosis?
- silent
- missense
- nonsense
- deletion
Answer:
Nonsense
Explanation:
Nonsense mutations describe mutations that produce a premature stop codon. The stop codons are UAG, UAA, and UGA. A way in which this could arise is, for example, if there was a substution of a nucleotide in the mRNA codon UAC (which codes for the amino acid Tyrosine) to the nucleotide UAG (which codes for a stop codon).
The translation machinery would reach this codon, which signals that translation should be terminated. This would mean that the mRNA would be released, and a truncated (shortened) version of the amino acid would be produced. This is likely to be non-functional, and may even be marked for destruction by the cell.
Answer:
relaxes
Explanation:
Acetylcholine is the substance responsible for the transmission of nerve impulses from pre-postganglionic neurons, in the ganglia of the autonomic nervous system. At the level of the parasympathetic nervous system, the transmission between the postganglionic neuron and the effector organ also mediates. In addition, it is the mediator of the nerve transmission of the terminal motor plate.
There are large differences in the effects that Acetylcholine triggers at different cholinergic transmission sites
Intra-arterial injection near Acetylcholine produces muscle contraction similar to that caused by motor nerve stimulation. Decreased resting potential in isolated intestinal muscle and increased frequency of spike production, accompanied by increased tension. In the cardiac conduction system, nodes S-A and A-V, it produces inhibition and hyperpolarization of the fiber membrane; and pronounced decrease in depolarization speed. Central regulation of extrapyramidal motor function. Exciting effect of the basal ganglia that counteracts the inhibitory action of Dopamine. Although cholinergic innervation of blood vessels is limited, cholinergic muscarinic receptors occur in sympathetic vasoconstrictor nerves. The vasodilator effect on isolated blood vessels requires the presence of an intact endothelium. The activation of muscarinic receptors causes the release of a vasodilator substance - <u>relaxing factor derived from the endothelium - that diffuses to the smooth muscle producing </u><u>relaxation</u><u>.</u>
Answer:
<h2>Recombination rate or recombination frequency between locus A and locus C is either 2% or 50%.
</h2>
Explanation:
As given,
Recombination frequency between locus A and B is 35%, means that the distance between A and B is 35 cM.
Recombination frequency between locus B and C is 33% , means the distance between B and C is 33 cM.
Therefore, if the locus C is present between A and B, then the recombination frequency between A and C would be 2%
A-----C ----------B
A---C= 2%
A----B= 35%
B---C= 33%
So, here the recombination frequency between A and C is 2%, means their distance is 2 cM.
If the locus C is as, A---35---B--33----C ; A-----B------C
A-----B= 35%
B------C= 33%
A-----C= 33+35= 68%
As rule, maximum frequency can not exceed 50%, as here the Recombination frequency between A and C = 50%.
The inhibitor of the biochemical pathway typically is the product of that pathway
