This mutation type is a substitution mutation. Substitution mutations may be silent or may have adverse effects (missense mutation).
Adverse effects come about because the change in codons in mRNA transcribed from the DNA strand. A point substitution can change the amino acid being coded for in the particular polypeptide change. If that animo acid is a structural residue of the protein, the structure of the protein will be altered, which may or may not lead to a change in protein function. If that particular amino acid is a catalytic residue of the protein, it may alter the 3D conformation and charge of the active site (if protein is an enzyme) or the binding site of protein. Function of protein formed from mutated DNA will be lost or altered.
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OSTEOARTHRITIS,
OSTEOARTHROSIS, or
DEGENERATIVE ARTHRITIS
Even though New Zealand has a smaller population than Australia, it has a greater population density because it covers a much smaller area. Australia’s population is approximately five times larger than New Zealand’s while the area Australia covers is approximately 30 times larger than the area New Zealand covers.
walking or riding a bike instead of driving
turning off the lights when leaving a room
copying or printing on both sides of the paper
