Answer:
The most likely explanation for the truncated polypeptide -due to the substitution of cytosine for adenine- is that mutation introduced a stop codon in the middle of the gene.
Explanation:
A codon consists of three nucleotides -in the RNA chain- whose order determines a specific amino acid. Not all codons code for amino acids, as there are termination codons, also called stop codons, which are UAG, UGA and UAA.
If in Manny's computer model, the substitution of cytosine by adenine produced a termination codon, the synthesis of a peptide is stopped prematurely resulting in a truncated peptide.
Learn more:
Stop codon brainly.com/question/6183177
Answer:
If predominantly, we can't say of any treatment for progeria, aside from the routine observation of heart and blood vessel (cardiovascular) disease which is important in taking care of the health situation in the affected kids. Treatment relies majorly on the situation and clinical manifestations of the kid. At first, in 1999, the findings of the initial clinical drug trial for kids with an unusual rapid-aging disease, often referred to as Progeria, revealed positive results with a farnesyltransferase inhibitor (FTI), a drug initially designed to treat cancer.
The PATHWAY in gene expression to be TARGETED is progenin formulation---
The Progeria-forming mutation results in the formation of the protein progerin that disrupts the cell activities. Some areas of progerin's toxic impact on the body is due to the formation of a farnesyl group, Â that adheres to the progerin protein aiding it's disruption of the body's cells. FTIs means of action is through inhibition of the adhesion of the farnesyl group to progerin, decreasing the hazardous substances that leads to progerin.
The genetic medicine technique that acts as.an intervention tool gene therapy to regulate the gene that causes the stimulation and formation of the protein progenin.
Escalated cardiovascular disease results in death in the case of Progeria.
It's worthwhile to note that if the basic blood vessels can with time get better as a result of treatment, the treatment shows positive results. Slowing down stroke and aging manifestations will boost the chances of treatment.
The correct answers are ATMOSPHERE and BIOSPHERE. Nitrogen is most abundant in the ATMOSPHERE, but nitrogen can't be absorbed by the BIOSPHERE without the help of a special bacteria and without undergoing a process called nitrogen fixation.
Answer:
See the answer below
Explanation:
Let the disorder be represented by the allele a.
Since the disease is an autosomal recessive one, affected individuals will have the genotype aa and normal individuals will have the genotype Aa or AA.
Since the four adults are carriers, their genotypes would be Aa.
Aa x Aa
Progeny: AA 2Aa aa
Probability of being affected = 1/4
Probability of being a carrier = 1/2
Probability of not being affected = 3/4
(a) The chance that the child second child of Mary and Frank will have alkaptonuria = 1/2
(b) The chance that the third child of Sara and James will be free of the condition = 3/4
(c)
(d) If someone has no family history of the disorder, their genotype would be AA.
AA x aa
4 Aa
<em>The chance that a child with alkaptonuria will have an offspring with alkaptonuria if the child's mate has no family history </em>= 0
(e)
(f) <em>The chance that a child with alkaptonuria will have an offspring with alkaptonuria if the child's mate has no family history</em> = 0
