Question

Insulin is a hormone that travels through the blood to cells, triggering the cells to alter metabolic processes. insulin does not enter target cells, but instead binds to an extracellular receptor, starting a signal transduction pathway in the cell. put the steps of the signal transduction pathway in order from the circulation of insulin in the blood to the alteration of the cell\'s metabolism.

Answer 1

Following are the steps of the signal transduction in order from the circulation in the blood to teh alteration of the cell's metabolism.

1. Insulin circulates in the blood.

2. Insulin combines extracellularly with the insulin receptor and stimulates receptor tyrosine kinase.

3. The receptor tyrosine kinase phosphorylates another tyrosine kinase.

4. Proteins, which comprise of a SH2 domain determine the stimulated tyrosine kinase.

5. SH2 comprising proteins are stimulated by the phosphorylated receptor tyrosine kinase.

6. Alteration of cell metabolism takes place.