It has meanwhile been shown that the most sensitive cells are those that areundifferentiated, well nourished, dividing quickly and highly active metabolically. Amongst the body cells, the most sensitive are spermatogoniaand erythroblasts, epidermal stem cells, gastrointestinal stem cells.
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In photosynthetic cells, synthesis of ATP by the chemi-osmotic mechanism occurs during photosynthesis and respiration. Plants can only achieve photosynthesis during the day and then respire during the night because photosynthesis requires the sun's energy to perform the necessary reaction to produce oxygen.
1. Action potential reaches the axon terminal and depolarizes it.
2. Depolarization opens voltage-gated calcium channels, enabling influx of Ca into the neuron.
3. Calcium binds to specialized proteins on vesicles (containing pre-made acetylcholine) and triggers them to fuse with the neuron membrane at the synapse.
4. Exocytosis of acetylcholine into the synaptic cleft occurs.
5. Acetylcholine diffuses across the synapse and binds to nicotinic receptors on the end plate of the myocyte.
6. Activated nicotinic receptors, themselves ion channels, cause cation influx into the myocyte and generate an end plate potential. This eventually gives rise to the full depolarization within the myocyte that enables contraction.
